Dr A Khan
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
Salmonella are responsible for causing food poisoning and remain major global health problems. The bacteria reside in the intestines of humans and animals, and now it appears they can adhere to or colonise edible-plants. Infected farm-animals and fresh produce can harbor Salmonella, and subsequently enter the food chain. It has been estimated foodborne disease costs the UK economy in excess of £1 billion pounds every year. Our understanding of the underlying mechanisms by which Salmonella can adhere to or colonise plants is very limited. This has sparked scientific interest in understanding the interactions of human enteric pathogens with plants.
The aim of the studentship is to provide detailed molecular and cellular insights into how Salmonella can adhere to and colonise plants, and how the pathogen interacts with the host plant to establish its niche. We hypothesise these interactions may involve direct signalling through diffusible bacterial molecules.
A multidisciplinary team of scientists based in Newcastle, Durham, and Nottingham will use the latest state-of-the-art technologies in microbiology, plant sciences, proteomics, and molecular biology to address this hypothesis. The student will have the opportunity to spend time in the Co-supervisors and Collaborators laboratories to acquire complementary expertise and generate data.
The results generated will have important implications in understanding the biology of pathogen-plant interactions, and also provide avenues for the development novel Agri-Tech control measures. The translatable outcomes of this studentship are increasingly important with the growing threat of infectious antibiotic-resistant bacteria.
For further information see the website: https://www.ncl.ac.uk/camb
To apply
Please complete the online application form and attach a full CV and covering letter. Informal enquiries may be made to [Email Address Removed]
Funding Notes
This is a 4 year BBSRC studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£14,777 for 2018-19). The PhD will start in October 2019. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. There are 2 stages to the application process.
References
Salmonella Typhi sense host neuroendocrine stress hormones and release the toxin haemolysin E. Karavolos MH, Bulmer DM, Spencer H, Rampioni G, Baker S, Pickard D, Gray J, Fookes M, Winzer K, Ivens A, Dougan G, Williams P, and C. M. A. Khan
EMBO Reports 2011,12(3),252-258.
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