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Cytoskeleton self-organisation in skeletal muscle cells

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Disciplines: Physical Sciences, Biological and Medical Sciences,
Subjects: Biophysics, Biochemistry, Cell Biology / Development
Type: PhD Research Project

Project Description:

In this project, you will study the dynamic self-organisation of microtubules into paraxial arrays in differentiating skeletal myoblasts. You will use gene editing to fluorescently label endogenous cytoskeletal proteins and perform live cell imaging experiments. Further, you will use superresolution light microscopy techniques and electron microscopy to quantitatively assess changes in the microtubule array organisation upon specific perturbation to microtubule crosslinkers.

You will be supervised by Dr Anne Straube in the Centre for Mechanochemical Cell Biology at the University of Warwick. You will become part of an international and interdisciplinary environment that is well resourced with access to state-of-the-art equipment as well as a vibrant community with internal and external seminar series. For more information see: http://mechanochemistry.org/straube/#tab=join

You will expected to compete for scholarship funding. Thus you should hold or expect to achieve an excellent university degree (BSc, MSc or equivalent) in a relevant field, already have some research experience, prizes and/or publications. Applications for October 2017 entry will require application by mid January.

Please send an expression of interest including a statement of career intentions, a full CV (including list of publications), degree certificates or transcripts plus two academic references to Dr Straube ().

Funding Notes

You will expected to compete for scholarship funding. Thus you should hold or expect to achieve an excellent university degree (BSc, MSc or equivalent) in a relevant field, already have some research experience, prizes and/or publications. Applications for October 2017 entry will require application by mid January.

References

Mogessie, B., Roth, D., Rahil, Z. and Straube, A. (2015)
A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation.
eLife, 4:e05697. doi:10.7554/eLife.05697.

Straube, A. and Merdes, A. (2007)
EB3 regulates microtubule dynamics at the cell cortex and is required for myoblast elongation and fusion.
Current Biology, 17, 1318-1325.

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