About the Project
Reactive oxygen species (ROS) damage many cell components and are linked with age-related diseases, such as cancer, diabetes, neurodegenerative diseases, and also with decreased lifespan [1]. However, there is much to learn about how cell responses to ROS affect human health. This knowledge is vital to underpin the development of effective clinical strategies to ROS-linked disease. The post translational modification of proteins by ubiquitin, a highly conserved polypeptide, regulates fundamental processes including responses to ROS, the cell cycle, and DNA repair [2]. Furthermore, deregulated ubiquitination is linked to several age-related diseases therefore there is much interest in targeting ubiquitin pathway enzymes with drugs to treat certain diseases such as cancer [3]. Hence, it is essential to understand the normal functions and regulation of ubiquitination. Excitingly, our recent data suggests that conserved deubiquitinases (enzymes that remove ubiquitin modification) that are linked to human health, are regulated by ROS to inhibit key cell processes. Thus, the project, based in laboratories with international expertise of ROS responses and ubiquitin modification, will utilise state-of-the-art approaches and yeast (Saccharomyces cerevisiae) and mammalian cells as model systems, to build on our pilot work. The project aims to provide comprehensive understanding of the regulation of ubiquitination by ROS and how this acts to prevent inheritance of damaged cell components. Broad experience will be obtained of genetics, biochemical, cell biology, microscopy, molecular biology techniques and also techniques to investigate protein modification.
For further information see the website: http://www.ncl.ac.uk/camb/
To apply:
Please complete the online application form and attach a full CV and covering letter - https://forms.ncl.ac.uk/view.php?id=553440. Informal enquiries may be made to [Email Address Removed]
Funding Notes
This is a 4 year BBSRC studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£14,553 for 2017-18). The PhD will start in October 2018. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. There are 2 stages to the application process.
References
[1] Veal EA et al. (2007) Hydrogen peroxide sensing and signaling. Mol. Cell 26, 1-14.
[2] Doris KS et al. (2012) Oxidative stress responses involves oxidation of a conserved ubiquitin pathway enzyme. Mol. Cell. Biol. 32, 4472-81.
[3] Singh N, Singh AB (2016) Deubiquitinases and cancer: A snapshot. Crit. Rev. Oncol. Hematol. 103, 22-6.
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