• University of Manchester Featured PhD Programmes
  • Coventry University Featured PhD Programmes
  • Ross University School of Veterinary Medicine Featured PhD Programmes
  • Lancaster University Featured PhD Programmes
  • University of Birmingham Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
  • FindA University Ltd Featured PhD Programmes
Ludwig-Maximilians-Universität Munich Featured PhD Programmes
FindA University Ltd Featured PhD Programmes
EPSRC Featured PhD Programmes
Imperial College London Featured PhD Programmes
FindA University Ltd Featured PhD Programmes

PhD in Enantioselective Catalysis and developing Lewis base-mediated transformations

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Our research is currently directed towards developing catalytic methods for the promotion of a range of synthetic transformations with varying applications in enantioselective synthesis. Current projects include the use of N-heterocyclic carbenes and isothioureas as asymmetric nucleophilic or Lewis-base catalysts [1-6]; and physical organic mechanistic studies designed toward understanding the mechanism of both N-heterocyclic carbene and isothiourea mediated transformations [7-8]. The application of these methodologies to natural product synthesis is currently under development.

This research project will develop a range of new organocatalytic methods employing chiral Lewis-bases and will target cutting-edge problems within this area. The synthetic strategies that we develop will be used for the enantioselective synthesis of a range of target products, with application in target natural product synthesis.

Students interested in undertaking a PhD in the Smith group in this research area should register their interest as soon as possible. Informal enquiries can be made to Prof Andrew Smith () and see http://chemistry.st-andrews.ac.uk/staff/ads/group/index.html for more details.

Please see: http://www.st-andrews.ac.uk/chemistry/prospective/pg/ for the application procedure or e-mail for more information regarding PhD opportunities at St Andrews. We encourage applications from Chinese nationals through the St Andrews CSC Scheme (https://csc.wp.st-andrews.ac.uk/) and for the EPSRC CDT in Critical Resource Catalysis (http://www.criticat.org/)

Funding Notes

Funding for EU or UK students is available.


[6] T. H. West, D. S. B. Daniels, A. M. Z. Slawin and A. D. Smith, “An Isothiourea-catalyzed Asymmetric [2,3]-Rearrangement of Allylic Ammonium Ylides”, J. Am. Chem. Soc., 2014, 136, 4476-4479. DOI: 10.1021/ja500758n.
[7] R. S. Massey, C. J. Collett, A. G. Lindsay, A. D. Smith and A. C. O'Donoghue, “Proton Transfer Reactions of Triazol-3-ylidenes: Kinetic Acidities and Carbon Acid pKa Values for Twenty Triazolium Salts in Aqueous Solution”, J. Am. Chem. Soc. 2012, 134, 20421–20432. DOI 10.1021/ja308420c.
[8] C. J. Collett, R. S. Massey, O.R. Maguire, A. S. Batsanov, A. C. O'Donoghue and A. D. Smith, “Mechanistic insights into the triazolylidene-catalysed Stetter and benzoin reactions: role of the N-aryl substituent”, Chem. Sci., 2013, 4, 1514-1522

How good is research at University of St Andrews in Chemistry?
(joint submission with University of Edinburgh)

FTE Category A staff submitted: 37.30

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully

Cookie Policy    X