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PhD in Enantioselective Catalysis and developing Lewis base-mediated transformations

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Our research is currently directed towards developing catalytic methods for the promotion of a range of synthetic transformations with varying applications in enantioselective synthesis. Current projects include the use of N-heterocyclic carbenes and isothioureas as asymmetric nucleophilic or Lewis-base catalysts [1-6]; and physical organic mechanistic studies designed toward understanding the mechanism of both N-heterocyclic carbene and isothiourea mediated transformations [7-8]. The application of these methodologies to natural product synthesis is currently under development.

This research project will develop a range of new organocatalytic methods employing chiral Lewis-bases and will target cutting-edge problems within this area. The synthetic strategies that we develop will be used for the enantioselective synthesis of a range of target products, with application in target natural product synthesis.

Students interested in undertaking a PhD in the Smith group in this research area should register their interest as soon as possible. Informal enquiries can be made to Prof Andrew Smith () and see http://chemistry.st-andrews.ac.uk/staff/ads/group/index.html for more details.

Please see: http://www.st-andrews.ac.uk/chemistry/prospective/pg/ for the application procedure or e-mail for more information regarding PhD opportunities at St Andrews. We encourage applications from Chinese nationals through the St Andrews CSC Scheme (https://csc.wp.st-andrews.ac.uk/) and for the EPSRC CDT in Critical Resource Catalysis (http://www.criticat.org/)

Funding Notes

Funding for EU or UK students is available.

References

[6] T. H. West, D. S. B. Daniels, A. M. Z. Slawin and A. D. Smith, “An Isothiourea-catalyzed Asymmetric [2,3]-Rearrangement of Allylic Ammonium Ylides”, J. Am. Chem. Soc., 2014, 136, 4476-4479. DOI: 10.1021/ja500758n.
[7] R. S. Massey, C. J. Collett, A. G. Lindsay, A. D. Smith and A. C. O'Donoghue, “Proton Transfer Reactions of Triazol-3-ylidenes: Kinetic Acidities and Carbon Acid pKa Values for Twenty Triazolium Salts in Aqueous Solution”, J. Am. Chem. Soc. 2012, 134, 20421–20432. DOI 10.1021/ja308420c.
[8] C. J. Collett, R. S. Massey, O.R. Maguire, A. S. Batsanov, A. C. O'Donoghue and A. D. Smith, “Mechanistic insights into the triazolylidene-catalysed Stetter and benzoin reactions: role of the N-aryl substituent”, Chem. Sci., 2013, 4, 1514-1522

How good is research at University of St Andrews in Chemistry?
(joint submission with University of Edinburgh)

FTE Category A staff submitted: 37.30

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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