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Determination of the structure of protein complexes from hydrogen-deuterium exchange and mass spectroscopy

Project Description

Determining how proteins interact with other molecules is key in understanding most biological process, development of novel therapeutics and biotechnology. The project involves the development and application of a novel approach that uses advanced experimental and computational techniques. The PhD candidate will employ molecular dynamics, ab initio modeling of protein structure, hydrogen deuterium exchange and mass spectrometry to determine how proteins interact and design molecules that inhibit binding. The skills gained will be highly valuable for a career in the academic and pharmacological and biotechnological sectors.

Funding Notes

White Rose BBSRC Doctoral Training Partnership in Mechanistic Biology
4 year fully-funded programme of integrated research and skills training, starting Oct 2019:
• Research Council Stipend
• UK/EU Tuition Fees
• Conference allowance
• Research Costs

At least a 2:1 honours degree or equivalent. We welcome students with backgrounds in biological, chemical or physical sciences, or mathematical backgrounds with an interest in biological questions.
EU candidates require 3 years of UK residency in order to receive full studentship

Not all projects advertised will be funded; the DTP will appoint a limited number of candidates via a competitive process.

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How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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