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Determination of the structure of protein complexes from hydrogen-deuterium exchange and mass spectroscopy

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  • Full or part time
    Dr E Paci
    Dr R Tuma
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Determining how proteins interact with other molecules is key in understanding most biological process, development of novel therapeutics and biotechnology. The project involves the development and application of a novel approach that uses advanced experimental and computational techniques. The PhD candidate will employ molecular dynamics, ab initio modeling of protein structure, hydrogen deuterium exchange and mass spectroscopy to determine how proteins interact and design inhibitors. The skills gained will be highly valuable for a career in the academic and pharmacological and biotechnological sectors.

Funding Notes

BBSRC White Rose Mechanistic Biology DTP 4 year studentship.
Studentships covers UK/EU fees and stipend (c.£14,296) for 4 years to start in Oct 2017. Applicants should have/be expecting at least a 2.1 Hons. degree in a relevant subject. EU candidates require 3 years of UK residency in order to receive full studentship.
Not all projects advertised will be funded; the DTP will appoint a limited number of candidates via a competitive process and the projects selected by the successful candidates will be funded.
There are 2 stages to the application process. Please see our website for more information: http://www.fbs.leeds.ac.uk/postgraduate/phdopportunities.php

References

Stable Single alpha-Helices Are Constant Force Springs in Proteins Wolny M, Batchelor M, Knight PJ, Paci E, Dougan L, and Peckham M

Myosin tails and single α-helical domains.
Batchelor M., Wolny M., Dougan L., Paci E., Knight PJ and Peckham M, Biochemical Society Transactions (2015) 43, 58-63

Extraction of accurate biomolecular parameters from single-molecule force spectroscopy experiments. Farrance, O.,
Paci, E., Radford, S. and Brockwell, D. (2015) ACS Nano 9: 1315-1324.

Effect of external pulling forces on the length distribution of peptides, Batchelor M, Gowdy J, Paci E Biochimica et Biophysica Acta 1850 (2015) 903–910

How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

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