Molecular mechanisms of regulating the stress response and chronological aging in yeast
Research into the biology of aging in different model organisms has identified several signalling pathways affecting lifespan. Among them, the conserved TOR pathway regulate lifespan in organisms from yeast to mammals. Active signalling through TOR limits lifespan in budding yeast, nematodes, fruit flies, and mice. The TOR pathway controls many aspects of cell physiology, promoting ribosome biogenesis, translation (and thus cell growth) and proliferation, but also inhibiting autophagy and the stress response. We use the yeast S.cerevisiae as a model to address how starvation-induced stress response is regulated and how this regulation is related to chronological aging.
Currently, two complementary approaches are adopted to address the issue. One is to reveal the genetic interaction network governing stress response and chronological aging. The other is to elucidate the molecular mechanisms by which the nutrient starvation signals are transmitted and converged on starvation-induced gene expression. Furthermore, the knowledge gained from both approaches is being applied to develop novel expression systems for biotechnology.
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