The development of experimental and computational approaches to dissect key signaling pathways involved in platelet function, diabetes and cancer.
My laboratory has been interested for many years in understanding both normal signalling and where it goes wrong in disease.
What has become clear is that analysing individual signalling pathways does not necessarily lead to the insights needed into the changes that occur in disease states. This needs a more systems level approach looking at how multiple signalling pathways integrate to bring about regulated cell function. This brings with it many challenges at an experimental level.
We are currently working to develop integrated experimental and computational modelling approaches to address this key issue. We have ongoing projects in a number of important areas including integrating signalling in platelets function (buliding a "virtual platelet" model), insulin regulation of PI 3-kinase - TOR signalling in diabetes, and integrating growth factor and oestrogenic signalling in breast cancer.