Non-antibody binding proteins; a novel discovery platform.
We have recently developed a new non-antibody binding protein scaffold called Adhiron, that is small (82 aa) and extremely robust. We have produced extremely high quality phage display libraries. We routinely select Adhirons against a range of molecular targets including proteins, peptides, organic and inorganic molecules. We are interested in further engineering an tailoring the scaffold for a range of applications.
The project will involve training in a range of molecular biology and protein biochemistry, recombinant protein purification and biochemical and biophysical characterisation of proteins.
Student must be able to provide funding for their academic fees, research costs and living costs.
Tiede, C. et al., Adhiron: A stable and versatile peptide display scaffold for molecular recognition applications. Protein Engineering Design and Selection 27, 145-155, 2014. doi:10.1093/protein/gzu007
How good is research at University of Leeds in Biological Sciences?
FTE Category A staff submitted: 60.90
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