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The regulation of gene expression in mammalian cells

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

About This PhD Project

Project Description

My research examines the regulation of gene expression in eukaryotic cells and the role that this plays in tumourigenesis. My group studies two transcription factors that bind to DNA using very different structural motifs: the papillomavirus E2 protein and the homeodomain protein PRH. Our work has provided several significant insights into how transcription factors find their binding sites and regulate gene expression. Current work has shown that PRH regulates TGFb signalling via transcriptional control of Endoglin, a TGFb co-receptor.

Webpage: http://www.bristol.ac.uk/biochemistry/research/kg.html

References

1. Kershaw, R. M., Siddiqui, Y. H., Roberts, D, Jayaraman, P. S., and Gaston K. (2014) PRH/Hhex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin. Oncogene, 33:5592-600

2. Noy, P., Sawasdichai, A., Jayaraman, P.S., and Gaston, K. (2012) CK2 inactivates PRH/Hhex using multiple mechanisms to derepress VEGF signalling and promote cell survival. Nucleic Acids Research, 40:9008-9020.

3. Brown, C., Campos Leon, K., Strickland, M., Williams, C., Fairweather, V., Brady, R. L., Crump, M. P., and Gaston, K. (2011) Protein flexibility directs DNA recognition by the papillomavirus E2 proteins. Nucleic Acids Research, 39:2969-80.

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