Medical Research Council, Harwell Featured PhD Programmes
Imperial College London Featured PhD Programmes
Imperial College London Featured PhD Programmes
Norwich Research Park Featured PhD Programmes
University of Manchester Featured PhD Programmes

C. elegans mitochondrial protein import

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Prof P Kuwabara
  • Application Deadline
    Applications accepted all year round

About This PhD Project

Project Description

Mitochondria are the metabolic powerhouses of the cell and dysfunction of these organelles are associated with the development of age-related pathologies, including cancers and degenerative diseases. Although mitochondria have their own genomes, nuclear genes encode a vast majority of the proteins contributing to mitochondrial biogenesis.

In this project, our lab is undertaking a collaborative and multidisciplinary approach toward understanding the structure and function of the eukaryotic mitochondrial protein import machinery in health and disease using the model organism C. elegans. Advances in genome engineering and cryo-EM are particularly timely and will facilitate exploration of the multiprotein translocons of the inner and outer mitochondrial membrane, TIMs and TOMs, respectively.

References

1. Merry A, Qiao M, Hasler M, Kuwabara PE (2014) RAD-6: Pyrimidine synthesis and radiation sensitivity in Caenorhabditis elegans. Biochem J. 458: 343-53.

2. Joyce PI, Satija R, Chen M, Kuwabara PE (2012) The Atypical Calpains: Evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration. PLoS Genet 8(3): e1002602. doi:10.1371/journal.pgen.1002602.

3. Vallin E* et al. (2012) A Genome-Wide Collection of Mos1 Transposon Insertion Mutants for the C. elegans Research Community. PLoS ONE 7(2): e30482. doi:10.1371/journal.pone.0030482.



FindAPhD. Copyright 2005-2018
All rights reserved.

Let us know you agree to cookies

We use cookies to give you the best online experience. By continuing, we'll assume that you're happy to receive all cookies on this website. To read our privacy policy click here

Ok