• University of Leeds Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
  • London School of Economics and Political Science Featured PhD Programmes
  • Carlos III Health Institute Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • University of Mannheim Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
University of Liverpool Featured PhD Programmes
University of Sussex Featured PhD Programmes
University of Westminster Featured PhD Programmes
Queen’s University Belfast Featured PhD Programmes
University of Manchester Featured PhD Programmes

C. elegans mitochondrial protein import

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

About This PhD Project

Project Description

Mitochondria are the metabolic powerhouses of the cell and dysfunction of these organelles are associated with the development of age-related pathologies, including cancers and degenerative diseases. Although mitochondria have their own genomes, nuclear genes encode a vast majority of the proteins contributing to mitochondrial biogenesis.

In this project, our lab is undertaking a collaborative and multidisciplinary approach toward understanding the structure and function of the eukaryotic mitochondrial protein import machinery in health and disease using the model organism C. elegans. Advances in genome engineering and cryo-EM are particularly timely and will facilitate exploration of the multiprotein translocons of the inner and outer mitochondrial membrane, TIMs and TOMs, respectively.

References

1. Merry A, Qiao M, Hasler M, Kuwabara PE (2014) RAD-6: Pyrimidine synthesis and radiation sensitivity in Caenorhabditis elegans. Biochem J. 458: 343-53.

2. Joyce PI, Satija R, Chen M, Kuwabara PE (2012) The Atypical Calpains: Evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration. PLoS Genet 8(3): e1002602. doi:10.1371/journal.pgen.1002602.

3. Vallin E* et al. (2012) A Genome-Wide Collection of Mos1 Transposon Insertion Mutants for the C. elegans Research Community. PLoS ONE 7(2): e30482. doi:10.1371/journal.pone.0030482.

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.
Email Sent

Share this page:

Cookie Policy    X