Applicants should hold or be about to achieve a First/Upper-Second (2.i) class degree in a relevant subject. BBSRC studentships are available to UK nationals/EU students who meet UK residency requirements (see View Website)
The successful candidate will receive a stipend at RCUK rates for 4 years (£14,296 per annum for 2016-17) and in addition will benefit from a £2,500 per annum stipend enhancement; fees will be met in full.
Applications to Dr Darerca Owen ([email protected]) by 16th December 2016, enclosing a cover letter, a detailed curriculum vitae and the names and contact details of two academic referees.
Rittinger, K. et al.(1997) Crystal Structure of a small G protein in complex with the GTPase-activating protein RhoGAP. Nature 388:693
Mott, H.R., et al.(1999) Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK Tyrosine Kinase. Nature 399:384.
Morreale, A. et al.(2000) Structure of Cdc42 complexed with the GTPase binding domain of PAK. Nat.Struct.Biol. 7:384
Mott, H.R. et al.(2003) Structure of the GTPase-Binding domain of Sec5 and Investigation of its Ral-binding Site J.Biol.Chem 278:17053
Owen, D. et al.(2003) Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and Protein Kinase C Related Kinase 1 (PRK1) J.Biol.Chem. 278:50578
Elliot-Smith, A.E. et al.(2005) Specificity Determinants on Cdc42 for binding its effector protein ACK Biochemistry 44:12373
Elliot-Smith, A.E. et al.(2007) Double mutant cycle thermodynamic analysis of the hydrophobic Cdc42-ACK protein:protein interaction Biochemistry 46:14087
Modha, R. et al.(2008) The Rac1 Polybasic Region Is Required for Interaction with Its Effector PRK1 J.Biol.Chem. 283:1492
Owen, D. et al.(2008) The IQGAP1-Rac1 and IQGAP1-Cdc42 Interactions: Interfaces differ between the complexes J.Biol.Chem. 283:1692
Mott, H.R. and Owen, D.(2009) 'Structure of Rho Family Targets' Handbook of Cell Signalling 2:1827
Fenwick, R.B. et al.(2010) The RalB-RLIP76/RalBP1 complex reveals a novel mode of Ral-effector interaction. Structure 18:985
Hutchinson, C.L. et al.(2011) Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1. Biochemistry 50:2860
Rajasekar, K.V. et al.(2013) The structure of the RLIP76 (RalBP1) RhoGAP domain-Ral binding domain dyad: fixed position of the domains leads to dual engagement of small G proteins at the membrane. Structure 21:2131
Hutchinson, C.L. et al.(2013) Differential binding of RhoA, B and C to the PRK isoforms PRK1, 2 and 3: PRKs have highest affinity for RhoB. Biochemistry 52:7999
Mott, H.R.&Owen, D.(2014) Structure and Function of RLIP76 (RalBP1): an intersection point between Ras and Rho signalling. Biochemical Society Transactions 42:52
Campbell, L. et al.(2015) Thermodynamic mapping of effector protein interfaces with RalA and RalB. Biochemistry 54:1380
Mott, H.R.&Owen, D.(2015) Ras superfamily Effector Complexes: What have we learned in two decades? Critical Reviews in Biochemistry and Molecular Biology 50:85
Watson, J.R. et al.(2016) Investigation of the Interaction Between Cdc42 and its Effector TOCA1: Handover of Cdc42 to the Actin Regulator N-WASP is Facilitated by Differential Binding Affinities. J. Biol. Chem. 291:13875
Thomas, J.T. et al.(2016) Inhibition of Ral GTPases using a stapled peptide approach. J. Biol. Chem. 291:18310
FTE Category A staff submitted: 189.63
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