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Molecular Basis of Group A Streptococcus invasive disease

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Applications are invited for a PhD studentship to study the molecular basis of Group A Streptococcus (GAS) invasive disease. The objectives are to use genetic-, structural-, biochemical-, and cell culture-based techniques to determine the mechanisms by which GAS interacts with human tissues and components of the host immune system to promote severe systemic disease. The project will be split between the School of Biochemistry and the Oral Microbiology Group within the School of Oral and Dental Sciences. This provides an excellent opportunity to develop a wide range of interdisciplinary skills within vibrant research teams addressing a significant biomedical problem.

Candidates should have a BSc Hons degree at the level of 2.1 or above in Microbiology, Molecular Biology, Biochemistry or related sciences. The studentship provides the cost of fees for a UK or EU resident student, and a stipend based on current studentship rates. The student will be jointly supervised by Dr Paul Race (School of Biochemistry; ) and Dr Angela Nobbs (Oral Microbiology; ). Interested applicants are invited to contact either supervisor for further information or discussion. Applications should be made online via the University of Bristol postgraduate degree application web site (http://www.bristol.ac.uk/prospectus/postgraduate/2012/apply.html) before Friday 27th April 2012. Please select ’Oral and Dental Science (PhD)’ within the Faculty of Medicine and Dentistry and enter details of the studentship in the Research Details section of the form.

Funding Notes

The studentship provides the cost of fees for a UK or EU resident student, and a stipend based on current studentship rates.

References

S.E. Maddocks, C.J. Wright, A.H. Nobbs, J.L. Brittan, L. Franklin, N. Strömberg, A. Kadioglu, M.A. Jepson and H.F. Jenkinson (2011). Streptococcus pyogenes antigen I/II family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation. Molecular Microbiology 81: 1034-1049.

Race, P.R., Bentley, M.L., Melvin, J.A., Crow, A., Hughes, R.K., Smith, Sessions, R.B., W., Kehoe, M., McCafferty D.G. and Banfield, M.J. (2009). Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism. J. Biol. Chem. 284: 6924-6933.

A.H. Nobbs, R. Rosini, C.D. Rinaudo, D. Maione, G. Grandi and J.L. Telford (2008). Sortase A utilizes an ancillary protein anchor for efficient cell wall anchoring of pili in Streptococcus agalactiae. Infection and Immunity 76: 3550-3560.

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