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Mucosal Vaccines - using Bacillus subtilis spores to develop vaccines and adjuvants against disease

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Heat stable bacterial spores are being used as novel mucosal vaccines. Spores of Bacillus subtilis have been used successfully as both vaccines and adjuvants against a number of diseases. They can be engineered to express antigens or alternatively coated with antigen. Both live and killed spores can be used. Spore vaccines promote balanced Th1/Th2 immune responses and in the MALT promote high levels of secretory IgA. We are currently working on a number of vaccines including Clostridium difficile, influenza and TB. We work with a number of pharma companies with both human and veterinary vaccine projects. The project would incorporate one or more aspects of the spore vaccine technology and would involve microbiology, genetic engineering, molecular biology, animal studies, cell culture and immunology. Thus, the project assigned would lead to the acquisition of a number of important skill-sets.

References

Huang, J.M., Hong, H.A., Van Tong, H., Hoang, T.H., Brisson, A., Cutting, S.M., 2010. Mucosal delivery of antigens using adsorption to bacterial spores. Vaccine 28, 1021-1030.
Permpoonpattana, P., Hong, H.A., Khaneja, R., Cutting, S.M., 2012. Evaluation of Bacillus subtilis strains as probiotics and their potential as a food ingredient. Benef Microbes 3, 127-135.
Permpoonpattana, P., Hong, H.A., Phetcharaburanin, J., Huang, J.M., Cook, J., Fairweather, N.F., Cutting, S.M., 2011. Immunization with Bacillus spores expressing toxin A peptide repeats protects against infection with Clostridium difficile strains producing toxins A and B. Infection and immunity 79, 2295-2302.
Song, M., Hong, H.A., Huang, J.M., Colenutt, C., Khang, D.D., Nguyen, T.V., Park, S.M., Shim, B.S., Song, H.H., Cheon, I.S., Jang, J.E., Choi, J.A., Choi, Y.K., Stadler, K., Cutting, S.M., 2012. Killed Bacillus subtilis spores as a mucosal adjuvant for an H5N1 vaccine. Vaccine 30, 3266-3277.

How good is research at Royal Holloway, University of London in Biological Sciences?

FTE Category A staff submitted: 24.00

Research output data provided by the Research Excellence Framework (REF)

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