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Ion Channel Clustering Mechanisms

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  • Full or part time
    Dr S M Prince
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

The aim of the study is to investigate the organization of ion channels in the membranes of excitable cells by scaffold proteins, and to discover how the properties of the channels are modified by these interactions. The work will encompass major structural and proteomic techniques as well as techniques relevant to biotechnology including biochemical assays, protein over-expression and purification, liquid chromatography, bioinformatics and reconstitution. The studentship will use computational and structural biology techniques to investigate the molecular architecture involved in the generation and propagation of electrical signals in cell membranes.

Funding Notes

This project has a Band 2 fee. Details of our different fee bands can be found on our website. For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website. Informal enquiries may be made directly to the primary supervisor.

References

Fomina, S., Howard, T.D., Sleator, O.K., Golovanova, M., O'Ryan, L., Leyland, M.L. Grossmann, J.G, Collins, R.F., Prince S.M “Self-directed assembly and clustering of the cytoplasmic domains of inwardly rectifying Kir2.1 potassium channels on association with PSD-95” Biochim. Biophys Acta. (2011) 1808: 2374-89.

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