Muscle afferent contributions to the control of breathing in man at University of Birmingham on FindAPhD.com

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Dr M.J. White Applications accepted all year round Self-Funded PhD Students Only

About the Project

A role for muscle afferent feedback in modifying the ventilatory response to exercise in man has recently been suggested. Our laboratory has provided further evidence in support of this idea. This project aims to investigate how altering muscle afferent feedback might influence the control of breathing in man. There are sport related applications of this work as well as relevance to patients with chronic heart failure or chronic obstructive pulmonary disease.

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References

Richard Bruce and Michael White (2012) Muscle afferent activation causes ventilatory and cardiovascular responses during concurrent hypercapnia in humans. Exp. Physiol. 97 (2) 208-218.
See also viewpoint on this paper by J. H. Coote. (2012) Muscles bring breathing alive. Exp Physiol 97 (2) 207.
And F1000 citation, “must read”.
Richard M. Bruce and Michael J. White (2015). The ventilatory response to muscle afferent activation during concurrent hypercapnia in humans: central and peripheral mechanisms. Exp Physiol. 100(8) 896-904. See also the Viewpoint on this article by Thomas Olson. http://onlinelibrary.wiley.com/doi/10.1113/EP085327/abstract
Bruce RM, Turner A, White MJ.Ventilatory responses to muscle metaboreflex activation in chronic obstructive pulmonary disease.
J Physiol. 2016 Oct 15;594(20):6025-6035. doi: 10.1113/JP272329.

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Muscle afferent contributions to the control of breathing in man

University of Birmingham School of Sport, Exercise and Rehabilitation Sciences