• Carlos III Health Institute Featured PhD Programmes
  • University of Mannheim Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • London School of Economics and Political Science Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
University of Liverpool Featured PhD Programmes
Imperial College London Featured PhD Programmes
University of Kent Featured PhD Programmes
University College London Featured PhD Programmes
University of Manchester Featured PhD Programmes

Gene and Cell Therapy For Muscular Dystrophy, Muscular Atrophy, Diabetes and Metabolic conditions

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Dr Foster
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Skeletal muscle development is a complex process and a number of regulatory factors for the different steps involved in stem cell activation and proliferation through to multinucleated, post-mitotic cells have been identified. Skeletal muscle size is dynamic and responsive to extracellular signals such as mechanical load, neural activity, hormones, growth factors, and cytokines. The loss of skeletal muscle tissue or function has a major impact on public health; a variety of conditions result in the loss of muscle, including disease-related loss (cachexia), age-associated loss (sarcopenia), enforced inactivity, such as bed rest, and muscular dystrophies.

The program will seek to develop novel medicines using strategies based on evaluating either novel pharmaceutical, antisense reagents (exon skipping), viral technologies (adeno-associated virus and lentivirus) or immunotherapies to either re-introduce normal copies of gene that are mutated in human health, alter gene expression profiles to enhance the environmental milieu of muscle or to improve oxidative stress that will positively impact muscle structure or function. The developed medicines will be potential therapeutic strategies for muscular dystrophies, age-related or disease related muscle loss or metabolic disease.



How good is research at University of Reading in Biological Sciences?

FTE Category A staff submitted: 20.60

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities
Share this page:

Cookie Policy    X