• University of Cambridge Featured PhD Programmes
  • University of Pennsylvania Featured PhD Programmes
  • Staffordshire University Featured PhD Programmes
  • Aberdeen University Featured PhD Programmes
  • University of Tasmania Featured PhD Programmes
  • FindA University Ltd Featured PhD Programmes
University of York Featured PhD Programmes
Imperial College London Featured PhD Programmes
Norwich Research Park Featured PhD Programmes
Peter MacCallum Cancer Centre Featured PhD Programmes
University of Reading Featured PhD Programmes

Gene and Cell Therapy For Muscular Dystrophy, Muscular Atrophy, Diabetes and Metabolic conditions

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Skeletal muscle development is a complex process and a number of regulatory factors for the different steps involved in stem cell activation and proliferation through to multinucleated, post-mitotic cells have been identified. Skeletal muscle size is dynamic and responsive to extracellular signals such as mechanical load, neural activity, hormones, growth factors, and cytokines. The loss of skeletal muscle tissue or function has a major impact on public health; a variety of conditions result in the loss of muscle, including disease-related loss (cachexia), age-associated loss (sarcopenia), enforced inactivity, such as bed rest, and muscular dystrophies.

The program will seek to develop novel medicines using strategies based on evaluating either novel pharmaceutical, antisense reagents (exon skipping), viral technologies (adeno-associated virus and lentivirus) or immunotherapies to either re-introduce normal copies of gene that are mutated in human health, alter gene expression profiles to enhance the environmental milieu of muscle or to improve oxidative stress that will positively impact muscle structure or function. The developed medicines will be potential therapeutic strategies for muscular dystrophies, age-related or disease related muscle loss or metabolic disease.

http://www.reading.ac.uk/biologicalsciences/k-foster.aspx

http://www.linkedin.com/pub/keith-foster/6/996/353

How good is research at University of Reading in Biological Sciences?

FTE Category A staff submitted: 20.60

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.
Email Sent

Share this page:

Cookie Policy    X