Investigating a novel catalysis-based approach to access functionalised heterocyclic scaffolds
Heterocyclic motifs form the basis of many active pharmaceutical ingredients (API) and new hit/lead molecules against disease targets.
A novel transition-metal based reactivity mode discovered by the Davies group (formal cycloadditions using nucleophilic nitrenoids) provides efficient and convergent access to heterocyclic motifs that are of particular import in the pharmaceutical sector.
This project will seek deeper understanding of the control factors and mechanims in this new reactivity and explore the applicability of the method as a general tool for the preparation of novel functionalised heterocyclic motifs to enable academic and pharmaceutical discovery and development activities. The research is centred on synthetic organic chemistry and homogeneous catalysis. In addition, the project can offer the opportunity to explore mechanistic and organometallic aspects of gold catalysis alognside developing non-precious metal based catalysis.
The project is in collaboration with Eli Lilly. A researcher on this project will interact with Lilly scientists, and will spend a period of time during the PhD at their research facilities.
This project will link the Davies group’s expertise in the discovery of efficient new catalysis-based methods with Lilly scientists expertise in applying catalysis-based methods to drug discovery and scale-up synthesis of APIs.
Please contact Dr Paul Davies for more information (direct email or using the findaphd message box below)
For an overview of our work visit our website at:
Applicants should either hold, or be on course to achieve, a 1st class or high 2.1 degree in Chemistry (or an equivalent degree where Chemistry is the major component). We are looking for candidates with a deep interest in the practice and theory of synthetic chemistry and catalysis.
Applications will be assessed as they come in until the position is filled. In addition to applying online through the Graduate School portal, please email Dr Paul Davies with an up-to-date CV (listing your research experience and academic performance to date).
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FTE Category A staff submitted: 28.00
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