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Adaptive immunity in multiple sclerosis: studying the antigen specificity of autoreactive B cells in MS

  • Full or part time
    Dr S J Curnow
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Multiple sclerosis (MS) is a chronic inflammatory disease involving immune attack by autoreactive T cells and B cells. We have been studying the phenotype, frequency and antigen specificity of these adaptive immune cells in human MS. We have a particular interest in the early phase of the disease, whether this can predict disease progression, and how the immune response changes over time. The project currently available is to study the antigen specificity of autoreactive B cells in MS , both in the peripheral blood and those entering the cerebrospinal fluid. The research group uses a wide range of technologies including cell purification and culture, flow cytometry, real-time PCR, gene microarrays, immunofluorescence and immunohistochemistry microscopy.

To apply, please submit your CV and a covering email/letter for consideration by the Supervisor.

Funding Notes

Applications are invited from self-funding applicants only. Overseas applicants will need to meet the UoB English requirements which are IELTS of 7.0 overall with no less than 6.5 in any band or TOFEL IBT of 95 overall with no less than 22 in any band.

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