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Single cell pedigree analysis to understand the mechanisms of fate determination during T cell development, leukemia, and immune responses

Project Description

Understanding how cell fate programming works will lead to improved diagnostic and therapeutic opportunities for leukemia, and to improved immunotherapies for cancer and infectious disease.

We have developed new methods for imaging single cells and their progeny through many generations of T cell development and activation. These methods mean that we can now assemble pedigrees that describe both the relationships between different differentiation stages, and molecular and behavioral attributes of their ancestors and progeny. We are now developing new computational approaches to analyse these pedigrees, and to determine the relative contributions of genetic, epigenetic, extrinsic and stochastic influences on fate determination.

This PhD project will involve development of new computational approaches to determine how behaviours in the T cell progeny (differentiation, growth, death, division) are influenced by ancestory, intrinisic and extrinsic cues.

The Russell lab explores how blood cell signalling influences fate decisions during development and immune responses. This will help to improve immunotherapies for cancer and infectious disease, and to understand how leukemia occurs when development goes wrong. Key for our research approach is to develop and apply new imaging and computational approaches, and for this the lab is partly located in the Centre for Micro-Photonics, Swinburne University.

Funding Notes

All PhD students at Peter Mac must have a scholarship from The University of Melbourne or through another government, trust or philanthropic organisation. Before applying for a scholarship, you must have agreed on a project with an institute supervisor.

For further information about the university application process, see:
View Website

For further information regarding scholarships (both local and international), see:
View Website
Closing dates for applications for scholarships to commence in 2017: Round 1 -31 October 2016; Round 2 - 18 Dec 2016.

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