Inflammation, the immune system and neurological disease
Inflammation is now recognised as a key contributor to neuronal injury in both acute and chronic neurodegenerative disease. Many studies in this area have focussed on the post-injury inflammatory response and in particular on the role of specific cytokines in the central nervous system. A key mediator, identified from both experimental and clinical studies, is interleukin-1 and this has been the focus of much of our research for the last few years. Increasing interest has now also been focussed on the peripheral response to injury and that the inflammatory status of an individual represents a key risk factor. This is particularly true for acute conditions, such as stroke, where preceding infection is a major risk factor, but this may also be true for chronic conditions, such as epilepsy and Alzheimer’s disease.
This project will assess the contribution of inflammation, peripheral and central, before and after injury, using appropriate experimental paradigms.
This project has a Band 3 fee. Details of our different fee bands can be found on our website. For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website. Informal enquiries may be made directly to the primary supervisor.
• Denes A, Pinteaux E, Rothwell NJ & Allan SM (2011) Interleukin-1 and stroke: biomarker, harbinger of damage, and therapeutic target. Cerebrovasc Dis. 32:517-27.
• Brough D, Tyrrell PJ & Allan SM (2011) Regulation of interleukin-1 in acute brain injury. Trends Pharmacol. Sci. 32:617-22.