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New Anticancer Drugs from Daffodils

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

More than 1 in 3 of us will develop cancer of some sort at some stage, fortunately, due to great advances in drugs many will be successfully treated. However, the fight against cancer continues as many diseases, such as pancreatic, prostate and brain cancers, remain difficult to treat. Furthermore, drug resistance means there is a constant need to develop new drugs. Our research is focused on compounds originally found in nature, such as daffodils, which show potent and selective anticancer activity. We take inspiration from these natural compounds and have developed new ways of making synthetic derivatives which are more drug-like and have the potential to deliver new classes of drug treatments for a range of cancers. Using our novel route, a PhD studentship would generate various new drug-like compounds which will be screened for anticancer activity, with the aim to identify potential new therapeutics for further drug development.
Our research is based on the efficient synthesis of simplified analogues of natural products which display various biological activities, and we have several projects at various stages. We are ideally situated in a vibrant Department with the potential to apply synthetic organic chemistry to biological problems with excellent training opportunities.

Dr Lorenzo Caggiano (, Twitter @LorenzoCaggiano)

References

- Research Group Webpages: http://people.bath.ac.uk/lc287/
- Publications: http://people.bath.ac.uk/lc287/publications.html
- Interview with Dr Phil Hammond for BBC Radio Bristol “Saturday Surgery” programme (listen here http://tinyurl.com/nycudm5)
- Public lecture (from 31 mins): http://tinyurl.com/ng7p4xv

How good is research at University of Bath in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 54.20

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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