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Dissecting the roles of PAWS1/FAM83G and the FAM83 family in cells and human diseases

  • Full or part time
    Dr Sapkota
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

PAWS1/FAM83G, a member of the uncharacterised FAM83 family of proteins, was discovered in our lab as an interactor of SMAD1 and a modulator of bone morphogenetic protein (BMP) signalling. Further investigations have uncovered key roles for PAWS1 in transcription, cell proliferation, development and cancer independently of BMP signalling. However, the precise molecular and biochemical mechanisms by which PAWS1 and the other members of the FAM83 family operate in cells remain a mystery. Prospective PhD candidates will exploit cutting-edge technologies, including CRISPR/Cas9 genome editing, mass spectrometry, ChIP and RNA sequencing as well as transgenic mouse models, to establish the physiological roles and regulation of PAWS1 and other members of the FAM83 family.

Funding Notes

We offer a 4 year studentship in which you would join a particular lab in the Unit. However, we strongly encourage prospective students to become part of the 4-year PhD programme in which you carry out rotation projects in two labs within the Unit (View Website). This studentship is jointly funded by the Medical Research Council and the University of Dundee and carries a tax-free stipend of £20,000 per annum

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