Dissecting the roles of PAWS1/FAM83G and the FAM83 family in cells and human diseases
Some recent discoveries in our lab have established key roles for relatively uncharacterised PAWS1/FAM83G, and the FAM83 family of proteins to which PAWS1 belongs, in tissue homeostasis, development and disease. One of the major focus of the lab is to understand how PAWS1 and the FAM83 family function and are regulated in cells and how their malfunction manifests in human diseases. Prospective PhD candidates will exploit cutting-edge technologies, including CRISPR/Cas9 genome editing, mass spectrometry, ChIP and RNA sequencing as well as transgenic mouse models, to establish the physiological roles and regulation of PAWS1 and other members of the FAM83 family. Advancing new technologies to address fundamental biological questions is another area of our interest. With this in mind, we aim to develop and test applications of the Affinity-directed PROtein Missile (AdPROM) system, which combines CRISPR/Cas9 and nanobodies to target endogenous proteins, for research into protein function and drug discovery.
We offer a 4 year studentship in which you would join a particular lab in the Unit. However, we strongly encourage prospective students to become part of the 4-year PhD programme in which you carry out rotation projects in two labs within the Unit (http://www.ppu.mrc.ac.uk/studentships/phd_projects.php). This studentship is jointly funded by the Medical Research Council and the University of Dundee and carries a tax-free stipend of £20,000 per annum