• University of Mannheim Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • Carlos III Health Institute Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • University of Cambridge Featured PhD Programmes
  • University of Bristol Featured PhD Programmes
  • London School of Economics and Political Science Featured PhD Programmes
Ludwig-Maximilians-Universität Munich Featured PhD Programmes
University of Kent Featured PhD Programmes
University of Sussex Featured PhD Programmes
Imperial College London Featured PhD Programmes
National University of Singapore Featured PhD Programmes

Regulation of protein degradation by the ubiquitin system

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Protein degradation is a fundamental process in cells that is important for timely elimination of damaged proteins. This process relies on modification of proteins with ubiquitin, a signal to target destruction of modified proteins via the proteasome. Failure to eliminate damaged/misfolded proteins is an underlying cause of age-related diseases such as Alzheimer’s and Parkinson’s disease. Excitingly, we have recently discovered a new family of proteins that regulate protein degradation signals. The aim of this project is to decipher how protein homeostasis is regulated by these newly identified players. In your PhD, you will employ a range of techniques including biochemical approaches, state-of-the-art ubiquitin proteomics, mouse models and CRISPR/Cas9 genome-editing methods to elucidate new layers of control in protein degradation, research that will advance our understanding of neurodegenerative diseases.

Funding Notes

We offer a 4 year studentship in which you would join a particular lab in the Unit. However, we strongly encourage prospective students to become part of the 4-year PhD programme in which you carry out rotation projects in two labs within the Unit (View Website). This studentship is jointly funded by the Medical Research Council and the University of Dundee and carries a tax-free stipend of £20,000 per annum

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.
Email Sent

Share this page:

Cookie Policy    X