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BBSRC White Rose Mechanistic Biology DTP 4 year studentship.
Studentships covers UK/EU fees and stipend (c.£14,553) for 4 years to start in Oct 2018. Applicants should have/be expecting at least a 2.1 Hons. degree in a relevant subject. EU candidates require 3 years of UK residency in order to receive full studentship.
Not all projects advertised will be funded; the DTP will appoint a limited number of candidates via a competitive process and the projects selected by the successful candidates will be funded.
There are 2 stages to the application process. Please see our website for more information: http://www.fbs.leeds.ac.uk/postgraduate/phdopportunities.php
Daniel O’Brien* and van Oosten-Hawle,P. (2016). Regulation of cell nonautonomous proteostasis in metazoans. Essays in Biochemistry. 2016 Oct 15;60(2):133-142.
*post graduate co-author.
Tipping KW; van Oosten-Hawle P; Hewitt EW; Radford SE (2015). Amyloid fibres: inert end-stage aggregates or key players in disease? Trends in Biochemical Sciences, 2015. 40 (12):719-27
van Oosten-Hawle P, Morimoto RI. 2014. Organismal Proteostasis: role of cell nonautonomous regulation and intertissue stress signaling. Genes & Development. 2014 Jul 15; 28(14):1533-1543.
van Oosten-Hawle P, Porter RS, Morimoto RI. Regulation of organismal proteostasis by transcellular chaperone signaling. Cell 153:1366-78
Wieteska, L., Shahidi, S., Zhuravleva A. (2017) Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation. eLife (In Press).
Zhuravleva*, A.; Gierasch*, L.M. (2015). Substrate-binding domain conformational dynamics mediate Hsp70 allostery. Proc Natl Acad Sci USA 112, E2865-E2873 (*corresponding authors)
Zhuravleva, A., Clérico, E. M., and Gierasch, L. M. (2012). An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones. Cell 151, 1296-1307
FTE Category A staff submitted: 60.90
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