• University of Leeds Featured PhD Programmes
  • Carlos III Health Institute Featured PhD Programmes
  • University of Mannheim Featured PhD Programmes
  • London School of Economics and Political Science Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • University of Cambridge Featured PhD Programmes
University of Warwick Featured PhD Programmes
University of Bristol Featured PhD Programmes
Newcastle University Featured PhD Programmes
Imperial College London Featured PhD Programmes
Cardiff University Featured PhD Programmes

Cancer cell dynamics in various microenvironment

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Dr Itasaki
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Cancer growth is strongly influenced by cellular microenvironment. For example, genetically damaged cancer cells, that form tumors when grafted in adult bodies, stop malignant activities when implanted in embryos. Although embryos and cancer share similar features such as rapid growth, dynamic cell movement and changes in the differentiation state, embryos’ highly regulated morphogenesis contrasts with cancer’s aberrant growth and destructive cellular behaviour. What does make them different?

We employ in vitro 3D time-lapse system to reveal dynamics of cancer cells in defined conditions. For example, in co-culture of cancer cells and non-cancerous epithelial cells, we have revealed that cancer cells display a strong attraction to the non-cancerous epithelial cells, followed by engulfing and destruction of non-cancerous cells. Such aggressive cellular behavior is characteristic to cancer and was never seen in the conventional 2D culture (Ivers et al. and movies therein).

Using the 3D time-laps method, we will investigate the cancer cell dynamics in co-cultures with various origins, such as fibroblasts of embryonic versus adult origin. We first aim to recapitulate embryonic microenvironment that attenuates cancer-specific cellular behavior and then aim to elucidate the mechanism. Possible differences between adult and embryonic tissues are; the composition of extracellular matrix and growth factors that are produced mainly by fibroblasts, a lack of inflammatory response in embryos that would enhance cancer development, and differences in hormonal activity. By analysing cellular dynamics in various conditions in vitro, we aim to elucidate the mechanism whereby microenvironment attenuates the destructive cell behavior.

For further details and prior to applying online please email the project supervisor Nobue Itasaki directly on [email protected]

http://www.bristol.ac.uk/anatomy/research/staff/itasaki.html

Funding Notes

This is a self-funded PhD project.
Entry requirements: First-class honours degree (or equivalent) in a relevant subject.
Before applying on line, you are suggested to contact Dr Nobue Itasaki (email address is available on the University Website).
For information on international equivalent qualifications, please see the International Office website: http://www.bristol.ac.uk/international/

References

Ivers, L.P. et al. Dynamic and influential interaction of cancer cells with normal epithelial cells in 3D culture. Cancer Cell International 14:108, 2014
http://www.cancerci.com/content/14/1/108

Related Subjects

Share this page:

Cookie Policy    X