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Mitochondrial dynamics in human disease: understanding the underlying mechanisms using cell biological and molecular approaches


Project Description

Mitochondria are highly dynamic structures. They undergo continuous fusion and fission to maintain a healthy network by discarding dysfunctional mitochondria (Nature, 505, 335-343, 2014). Emerging evidence indicates that disruption of mitochondrial dynamics contributes to a wide range of age-related illnesses, including diabetes, cardiovascular and neuronal (Parkinson’s, Alzheimer’s) diseases and cancer. We have discovered a role for ion channels in mitochondrial dynamics and our aim is understand the underlying mechanisms using cell biological and molecular approaches.

Transgenic approaches will be used to understand the relevance of the mechanisms to disease. Novel chemicals will be tested for their potential to prevent excessive mitochondrial fission, and hence certain diseases. Collaborations exist with clinicians and chemists to determine the relevance of regulators of mitochondrial dynamics to a wide range of diseases and to promote translational research.

Techniques to be used include: cell biology, molecular biology, biochemistry, in vivo techniques including gene knock-out models, drug screening using high-throughput machines

Funding Notes

A bench fee of £12K will be required.
International students with their own government funding are welcome.
Students can also apply for fully funded, highly competitive Wellcome Trust studentships (View Website)

References

For publications from Sivaprasadarao’s group, see
http://www.fbs.leeds.ac.uk/staff/profile.php?un=phaass

How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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