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Synthetic Biology Pipeline for Discovery and Diversification of Novel, Bioactive Natural Products from Marine Cyanobacteria


Project Description

An IBIOIC/MASTS funded PhD studentship is available for an exceptional candidate with a strong background in micro/molecular biology. A background in natural product chemistry and organic compound analysis would also be beneficial. Candidates must have, or be expected to obtain, a degree in Chemistry, Biochemistry, Microbiology or an appropriate related subject.

Summary: The quest for new antibiotics, especially those with activity against Gram negative and recalcitrant bacteria, is urgent. Over 13 million lives world-wide are currently claimed each year due to infectious diseases. Over the last decade this figure has doubled due to the emergence of multi-drug resistant strains. Conversely very few new antibiotics have been introduced to the market in the last 40 years, with this limited number falling into only four new structural classes.1, 2 The Global cost of antimicrobial resistance to GDP is calculated as between $2.1 trillion-$124.5 trillion dollars. (RAND report) We propose to a marine microbial pipeline for the discovery of novel antibiotics with which to address AMR.

Funding Notes

Funded PhD studentship is available for an exceptional candidate with a strong background in micro/molecular biology. A background in natural product chemistry and organic compound analysis would also be beneficial. Candidates must have, or be expected to obtain, a degree in Chemistry, Biochemistry, Microbiology or an appropriate related subject. Upper second-class degree in Chemistry or related area.

Please note this PhD position will be part of the IBioIC CTP, please check this website for further details on the programme (View Website)

References

[1] G. D. Wright, ACS Infect. Dis. 2015, 1, 80
[2] J.S. Zarins-Tutt, R.J.M.Goss et al. Nat. Prod.Rep. 2016, 33, 54.
[3] J.S. Zarins-Tutt, R.J.M.Goss Emily Abraham and Rebecca J. M. Goss*, Prog. Mol. Biol.,Blue Biotechnology, 2017, 55, 159-186.

How good is research at University of St Andrews in Chemistry?
(joint submission with University of Edinburgh)

FTE Category A staff submitted: 37.30

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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