Noise in Cellular Power Stations
PhD Project: Imperial College Mathematics
Student Background: Theoretical Physics, Mathematics/Statistics, Electrical Engineering (Biological knowledge not required)
We have been investigating variation in cellular power stations (mitochondria) using a mix of ideas from stochastic processes, statistical physics, statistical inference and control theory. You can read more about our recent work in our blog: http://systems-signals.blogspot.co.uk/ We believe this is a particularly exciting area to study for two reasons. Not only does 1) mitochondrial (dys)function have deep connections to therapies for conditions like Parkinsons, Diabetes, ageing and Cancer (and we are working on these) it is 2) a topic that, though poorly understood, might be susceptible to the very basic (though mathematically nuanced) models that one constructs in theoretical and mathematical physics. This is an area where students can carve out a new scientific direction since the medical promise and scientific challenges easily exceed the number of theorists. The student will investigate the construction of such basic models and make connections with existing data and the work of our national and international collaborators. Though the project has experimental collaborators the project does not require experiments by the student or any biological background; however theorists that want to try their hand at experiment are most welcome. We are looking for enthusiasm and scientific intuition.
You can learn about the research of the systems and signals group on our site:
and from our blog:
Further enquiries - contact with a CV detailing academic performance (i.e. including as detailed as possible information about grades/marks or equivalent):
Nick Jones (Imperial Mathematics) http://wwwf.imperial.ac.uk/~nsjones/