Carbon-hydrogen (C–H) bonds are the most common, but least reactive in organic molecules. C–H functionalization is a reaction that selectively modifies these otherwise inert C–H bonds. Considering the high abundance of C–H bonds in organic molecules, their direct, selective conversion to a C–C, C–O or C–N bond (amongst others) offers a powerful method to add valuable complexity to a compound without resorting to functional group transformations, opening up several new directions for chemical synthesis in the 21st century. This Ph.D project will examine the synthesis of heteroaromatic motifs with relevance in natural products and medicinal chemistry using novel C-H functionalization reactions.
Suitable applicants will typically have a Honours degree and/or Masters degree in Chemistry or related subject. Contact Jon for further details