The in vivo bioimaging using PET (positron emission tomography) to determine the delivery of novel cancer therapeutic constructs
Supervisor Nguyen TK Thanh (primary) Biophysics Group, Department of Physics and Astronomy, UCL and Rafael T. M. de Rosales Division of Imaging Sciences & Biomedical Engineering, Kings
We have developed a novel construct of magnetic iron oxides nanoparticles (MNPs) and two chemotherapy drugs (doxorubicin and gemcitabine), which were loaded in a liposomal system to boost the therapeutic effect and reduced the systemic toxicity of the cancer treatment. The synergism and stability of the liposome have already been demonstrated in our in vitro study. However, MNPs are readily excreted by the kidney or taken up by the Kupffer cells in the liver. Thus the in vivo biodistribution of the thermosensitive liposome is vital for evaluating the efficiency and translating our result from bench to bedside. Biodistribution study by using radiotracer is one of the most efficient methods of tracking the drugs, MNPs, and liposomes in an animal model.
A. Hervault, M. Lim, C. Boyer, A. Dunn, D. Mott, S. Maenosono and N. T. K. Thanh (2016) Doxorubicin loaded dual pH- and thermo-responsive magnetic nanocarrier for combined magnetic hyperthermia and targeted controlled drug delivery applications. Nanoscale. DOI: 10.1039/c5nr07773g. Cover Page. Gold Open Access
Blanco-Andujar, C., Southern, P., Ortega, D., Nesbitt, S.A., Pankhurst, Q.A., Thanh, N.T.K.* (2015) High performance multi-core iron oxide nanoparticles for magnetic hyperthermia: microwave synthesis, and the role of core-to-core interactions. Nanoscale.. 7: 1768-1775 Impact Factor 6.7. Gold Open Access
A. Hervault and Thanh, N. T. K* (2014) Magnetic Nanoparticles-Based Therapeutic Agents for Thermo-Chemotherapy Treatment of Cancer. Nanoscale, 6: 11553-11573. Gold Open Access
L. Sandiford et al. Bisphosphonate-anchored PEGylation and Radiolabeling of Superparamagnetic Iron Oxide: Long-circulating Nanoparticles for In Vivo Multimodal (T1 MRI-SPECT) Imaging. ACS Nano. 2013, 500
R. T. M. de Rosales et al. Synthesis of 64Cu(II)-Bis(dithiocarbamate-Bisphosphonate) and Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual-Modality PET-MRI Agent, Angew. Chem. Int. Ed., 2011, 50, 5509-5513.
Please write in the subject line: PET. Due to large number of applicants only short listed students will be contacted.
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