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Functional magnetic nanoparticles for cancer treatment


Project Description

Cancer is still a leading cause of disease worldwide. Magnetic nanoparticles offers an exciting new alternative treatment, with local heating of affected areas allows to eliminate the side effect of current radio-or chemotherapy. The most cutting edge research has recently focused on the combination of heat treatment with traditional cancer drugs. That synergistic effect will enhance the treatment efficacy of both components compared to single mode of treatments.
The bottle-neck is still the functionalization of magnetic nanoparticle that can be use for clinical treatment.
In this project, the students will use chemical methods to conjugate different ligands with magnetic nanoparticles and testing their stability effect on cancer cells.
The synthesised high magnetic moment NPs will be characterised at UCL using DLS (Dynamic light scattering), transmission electron microscopy (TEM) for size, shape and monodispersity of nanomaterials, thereby enabling the determination of the successful synthesis. X-Ray diffraction (XRD) will also be used at later stage to characterise further the structure of materials, and Superconducting QUantum Interference Devices (SQUID magnetometer). The ligand conjugation will be investigated using FTIR and TGA.

The student needs to have strong back ground in chemical thesis, bioconjugation of nanoparticles.
The student can also experiements with cells with they desired.

Funding Notes

The studentship covers all fees for for 3.5 years.

References

Please write in the subject line: Functionalisation. Due to large number of applicants only short listed students will be contacted.

How good is research at University College London in Chemistry?

FTE Category A staff submitted: 62.00

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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