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The effect of hyperthermia on cells and protein expression


About This PhD Project

Project Description

Supervisor: Nguyen TK Thanh UCL Healthcare Biomagnetic and Nanomaterials Laboratory

Hyperthermia has been recently identified as a method to treat tumors. In our lab we develop focused ultrasound hyperthermia protocols for disease treatments. Our research showed that iron oxide nanoparticles in combination with magnetic field hyperthermia could show great potential on treating solid tumors such as glioblastoma. Magnetic Field Hyperthermia (MFH) has been identified as a possible cancer stem cell killer and as a result this strategy has rapidly moved to clinical trials. Here we propose to investigate the effects of focused ultrasound and magnetic field hyperthermia on cell function and proliferation, gene regulation and protein expression.


References:
[1]

Thermosensitive, Near-Infrared-Labeled Nanoparticles for Topotecan Delivery to Tumors Rosca et al. 2015 Mol Pharm 12 (05)
[2]

MRI-Guided Focused Ultrasound as a New Method of Drug Delivery, Gedroyc and Thanou Journal of Drug Delivery (2013)
[3]

A. Hervault, M. Lim, C. Boyer, A. Dunn, D. Mott, S. Maenosono and N. T. K. Thanh (2016) Doxorubicin loaded dual pH- and thermo-responsive magnetic nanocarrier for combined magnetic hyperthermia and targeted controlled drug delivery applications. Nanoscale. DOI: 10.1039/c5nr07773g. Cover Page.
[4]

C. Blanco-Andujar, P. Southern, D. Ortega, S.A. Nesbitt, Q.A., Pankhurst and Thanh, N. T. K*. (2016) Real -time tracking of delayed-onset cellular apoptosis induce d by intracellular magnetic hyperthermia. Nanomedicine. 11: 121-136.
[5]

Blanco-Andujar, C., Southern, P., Ortega, D., Nesbitt, S.A., Pankhurst, Q.A., Thanh, N.T.K.* (2015) High performance multi-core iron oxide nanoparticles for magnetic hyperthermia: microwave synthesis, and the role of core-to-core interactions. Nanoscale.. 7: 1768-1775

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