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Exploring epigenetic control of hair cell regeneration in the ear

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  • Full or part time
    Prof Streit
  • Application Deadline
    Applications accepted all year round
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Childhood deafness is among the most common birth defects, while age-related hearing loss affects more that 50% of people over 70. Many forms of deafness are associated with loss of hair cells, the sensory cells responsible for transforming sound information into electrical signals, which are then relayed to the brain. In mammals, including humans, once damaged hair cells cannot regenerate, except for a short period after birth from so-called supporting cells. This projects explores why supporting cells lose their regenerative potential over time. In particular, we will explore the epigenetic changes during this process, and how we can use this knowledge to design new strategies to promote hair cell regeneration. The student will be trained in modern molecular approaches like RNA-seq, ChIP-seq and data analysis as well as animal model systems to study hair cell regeneration. In addition to project specific training, lecture-based and problem solving courses are available, as well as many other training opportunities. The student will benefit from two supervisors with complementary expertise in ear formation and systems biology respectively. S/he will join an international team of researchers, have the opportunity to collaborate with different research groups and to present data international conferences. The successful candidate is enthusiastic about science, interested in regenerative and developmental biology, has a good understanding of molecular biology and a keen interest in bioinformatics, and enjoys working in a team.

Related Subjects

How good is research at King’s College London in Allied Health Professions, Dentistry, Nursing and Pharmacy?
Dentistry

FTE Category A staff submitted: 52.95

Research output data provided by the Research Excellence Framework (REF)

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