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From single molecules to interacting clusters of calcium releasing channels

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  • Full or part time
    Dr Thul
    Prof Avitabile
  • Application Deadline
    Applications accepted all year round
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

A key question in understanding living organisms is how complex dynamics evolves from a small set of cell types and a limited number of signalling molecules. One approach that has been adapted by almost every cell type is the use of calcium as a key regulator. Calcium controls functions as diverse as the heartbeat, neural information processing and the secretion of hormones. At the centre of calcium signalling are calcium releasing channels. Importantly, these channels often form clusters, which in turn communicate with each other by the diffusion of calcium. In this project we will investigate different models for calcium releasing channels. Our aim is to understand what impact the choice of model has on the generation of physiologically relevant and measurable properties. This is a central question in computational cell biology, which becomes increasingly important as models are used as predictive tools in e.g. drug development. This project is ideally suited for students with a strong interest in computation who enjoy developing an advanced simulation framework.

Supervisors: Assistant Prof Ruediger Thul and Assistant Prof Daniele Avitabile – School of Mathematical Sciences

Eligibility/Entry Requirements: We require an enthusiastic graduate with a 1st class degree in Mathematics (other highly mathematical field), preferably of the MMath/MSc level, or an equivalent overseas degree (in exceptional circumstances a 2:1 class degree, or equivalent, can be considered).

For any enquiries please email: [email protected]

Funding Notes

Summary: UK/EU students - Tuition Fees paid, and full Stipend of £13,863 (2014/15 rate). There will also be some support available for you to claim for limited conference attendance.

References

Apply: This studentship is open now and will be available until it is filled. To apply please visit the University Of Nottingham application page: http://www.nottingham.ac.uk/pgstudy/apply/apply-online.aspx

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