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Development of novel assays for health markers, drugs and toxins.

This project is no longer listed in the FindAPhD
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  • Full or part time
    Prof Naughton
  • Application Deadline
    Applications accepted all year round
  • Awaiting Funding Decision/Possible External Funding
    Awaiting Funding Decision/Possible External Funding

Project Description

Considerable advances in the analytical capabilities of modern hyphenated instruments, such as LC-MS/MS, afford a new horizon in health testing. Our group have used this approach to track health behaviour in a number of studies including analysing hair samples for drug use, doping, toxicology and levels of hormones and vitamins.

The aim of this proposal is to harness the latest analytical advances to develop and apply new assays for biomarkers of health, diet and potentially, for disease along with drugs and toxins. The programme will benefit from (i) advances in sample preparation and testing expertise, (ii) advances in software capability afforded by Dynamic Multiple Reaction Monitoring (Dyn-MRM), and (iii) increasingly sensitive LC-MS/MS instrumentation. Using this approach, novel assays will be developed to study aspects of diet, health and drug use with new directions such as via hair analyses, providing considerable benefits of hair sampling (non-invasive collection, ease of storage and transport, low cost and infection risk). Self-funded applications are welcome.

Funding Notes

A first or 2:1 degree in a related subject area and a masters would be an advantage.

In the first instance, interested applicants should contact Prof Naughton at [email protected]

References

Hair-based rapid analyses for multiple drugs in forensics and doping: application of dynamic multiple reaction monitoring with LC-MS/MS. Shah I, Petroczi A, Uvacsek M, Ránky M, Naughton DP. Chem Cent J. 2014 Dec 13;8(1):73.

Analysis of 2-oxothiazolidine-4-carboxylic acid by hydrophilic interaction liquid chromatography: application for ocular delivery using chitosan nanoparticles. Al-Kinani AA, Naughton DP, Calabrese G, Vangala A, Smith JR, Pierscionek BK, Alany RG. Anal Bioanal Chem. 2015 Feb 10. [Epub ahead of print]

Exploring the role of vitamin D in type 1 diabetes, rheumatoid arthritis, and Alzheimer disease: new insights from accurate analysis of 10 forms. Shah I, Petroczi A, Naughton DP. J Clin Endocrinol Metab. 2014 Mar;99(3):808-16.

Determination of stanozolol and 3'-hydroxystanozolol in rat hair, urine and serum using liquid chromatography tandem mass spectrometry. Deshmukh NI, Zachar G, Petróczi A, Székely AD, Barker J, Naughton DP. Chem Cent J. 2012 Dec 22;6(1):162.

Simultaneous analysis of antiretroviral drugs abacavir and tenofovir in human hair by liquid chromatography-tandem mass spectrometry. Shah SA, Mullin R, Jones G, Shah I, Barker J, Petroczi A, Naughton DP. J Pharm Biomed Anal. 2013 Feb 23;74:308-13.

How good is research at Kingston University in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 17.22

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