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Imaging stem cell trafficking in injured heart and their vasculoprotective

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  • Full or part time
    Dr Kalia
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

We are offering an opportunity for an excellent candidate to apply for a 3 year PhD studentship. The project will utilise state-of-the-art confocal based intravital microscopy to image the kinetics of trafficking transplanted adult stem cells to injured murine organs. This intravital approach allows real-time and dynamic microcirculatory images to be captured in vivo and can quantitate many vascular disturbances including cellular interactions with endothelium and changes in vascular integrity and perfusion. The project will focus specifically on imaging the beating heart microcirculation in vivo following myocardial infarct. Different populations of adult stem cells, including haematopoietic and mesenchymal stem cells, will be tested to compare their homing capabilities. Strategies to enhance their retention within injured heart following systemic infusion will also be developed and tested using a range of in vitro adhesion assays and intravital imaging. The mechanisms by which these stem cell populations confer therapeutic benefit will also be identified with a focus on their vasculoprotective effects.

This project would be of interest to a biomedical scientist or clinical scientist wishing to explore the therapeutic potential of stem cells for inflammatory and ischemic human diseases. It offers an opportunity to study in an excellent research environment, in a research institute with world class facilities and resources devoted to understanding the mechanisms of human disease and driving new translational therapies for patients. We have opportunities available for exceptional candidates with knowledge, experience or an interest in stem cell biology, regenerative medicine, inflammation, cardiovascular disease, microvascular disturbances or in vivo models. Additional techniques to be used will include cell and tissue culture, cell viability assays, flow cytometry, confocal microscopy, immunohistochemistry, histology and laser Doppler flowmetry.

For more information about the Kalia research group please see:

http://www.birmingham.ac.uk/staff/profiles/cem/CVRS/Kalia-Neena.aspx

http://www.birmingham.ac.uk/research/activity/mds/domains/cardio-resp-neuro/vascular-inflammation/microcirculation-research-group/index.aspx

To find out more about studying for a PhD at the University of Birmingham, including full details of the research undertaken in each school, the funding opportunities for each subject, and guidance on making your application, you can now order your copy of the new Doctoral Research Prospectus, at: www.birmingham.ac.uk/students/drp.aspx

To apply, please submit your CV and a covering email/letter for consideration by Dr Kalia.

Dr Neena Kalia
[email protected]
+44 (0)121 415 8818

Funding Notes

We are an elite academic institution and competition for studentships is high. Shortlisted candidates would be required to demonstrate proof of English language skills (IELTS of 7.0 overall with no less than 6.5 in any band or Pearson Academic test.), present transcripts, and demonstrate relevant experience and training.

References

Kavanagh et al., Stem Cell Rev. 2014; 10(4):587-99.
Kavanagh et al., Cell Transplant. 2013;22(8):1485-99.
Kavanagh et al., Stem Cell Rev. 2011; 7(3):672-82.

Related Subjects

How good is research at University of Birmingham in Clinical Medicine?

FTE Category A staff submitted: 164.15

Research output data provided by the Research Excellence Framework (REF)

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