Developing an integrated microfluidic system for cell sorting
A fully funded studentship is available to work on an interdisciplinary project commencing as soon as possible.
Identifying and sorting targets are fundamental processes underlying broad applications in many fields (e.g. diagnostics, biology and drug development). Although fluorescence activated flow cytometry remains as an important means, it typically replies on external labeling of samples, which is not applicable to all kinds of cells or can compromise their functionalities.
In this project, we aim to develop an integrated sorting system based on Raman spectroscopy that provides an intrinsic chemical profile of a cell. This offers great advantages in enriching target cells based on specific functionalities in an externally label-free and non-destructive manner. The project will build upon our current prototype of Raman activated cell sorting in a 3D flow focusing microfluidic system. It will further develop nanostructured devices that magnify sample signals and thereby significantly enhance the performance of the system and the range of detectable samples. It is expected that the advanced system will have a broad range of applications, and within the lifetime of the project, its potential for sorting cancer cells in clinical diagnosis will be evaluated.
This PhD project is highly multi-disciplinary, and will allow the student to gain experience in a wide range of desirable skill sets. These include opportunities to gain expertise in Comsol programming, state-of-the-art micro- and nano-fabrication skills, image analysis, and other instrumental skills that are desirable in both the academic and industrial sectors.
Applicants should hold an upper second or first degree (or equivalent) in Engineering, Physics, or Chemistry. They should be self-motivated and keen to work within an interdisciplinary environment.
The studentship will cover home/EU tuition fees and provide a stipend of £14,057 per annum for 3.5 years. Both UK and EU nationals are eligible for this funding.
How to apply
Application for this scholarship is made by using the online system at the following link for admission as a postgraduate research student to the admission team in the Recruitment and International Office:
For an informal discussion or for further information on this project, potential applicants are encouraged to contact Dr Huabing Yin with a CV at Email: Huabing.firstname.lastname@example.org
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