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‘Molecular Syringes’ From Synthetic Biology and Bio-Orthogonal Chemistry

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  • Full or part time
    Prof Matthew Gibson
  • Application Deadline
    Applications accepted all year round
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

This PhD is part of a recently funded research project grant from the Leverhulme Trust Between Dr Matthew Gibson (Chemistry) and Dr Nicholas Waterfield (Warwick Medical School). The key aim of this project is to re-purpose natural molecular syringes (small nano-sized vehicles produced by micro-organisms) for biomedical applications. To achieve this we will use modern, bio-orthogonal synthetic chemistry to modify the surface (small molecules and polymers) of these nano-vehicles to enable them to specifically target and interact with (diseased) cells and tissue. The PhD position will focus on the synthetic chemistry aspects, but also have the opportunity to undertake biological testing (cell culture – full training provided). This is a unique opportunity to develop skills in synthetic chemistry, but apply them to cutting-edge biomedicine.
The GibsonGroup is a large, interdisciplinary group, located in state-of-the-art laboratories (New Oct 2014) for synthetic, analytical and biological chemistry and has access to world-leading facilities at Warwick Chemistry (see webpages).
If interested, please contact Dr M. Gibson.
http://www2.warwick.ac.uk/fac/sci/chemistry/research/gibson/gibsongroup/

Funding Notes

UK/EU only

References

Richards, S-J., Fullam, E.C, Besra, G., Gibson, MI. J. Mater. Chem. B, 2014, 2, 1490 - 1498 , "Discrimination between Bacterial Phenotypes using Glyco-Nanoparticles and the Impact of Polymer Coating on Detection Readouts"

Freese, C., Uboldi, C., Gibson, M.I., Unger, R.E., Weksler, B.B., Romero, I.A., Couraud, P.-O., Kirkpatrick, C.J., Particle and Fibre Toxicology, 2012, 9, 23 "Uptake and cytotoxicity of citrate-coated gold nanospheres: Comparative studies on human endothelial and epithelial cells"

How good is research at University of Warwick in Chemistry?

FTE Category A staff submitted: 34.80

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