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A Systems Biology Approach to the Optimisation of Fermentation Processes for Recombinant Protein Production (HLS/SE/DRFAPP7P/63595)

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  • Full or part time
    Prof Black
  • Application Deadline
    Applications accepted all year round

Project Description

The purpose of this project is to create deep systems biology level understanding of the stresses placed upon an organism, under a range of fermentation conditions required for the large scale manufacture of biocatalysts, through the use of the complex analytical techniques of metabolomics and proteomics. The project seeks to understand how variation in the genetic constructs and process conditions used to direct protein production can affect the organism and how these effects might be mitigated against, minimized and controlled by further re-design of the genetic components, feed medium and process conditions. The development of robust fermentation processes has economic advantages, through both cycle time reduction and raw material efficiencies and will have clear impact beyond this study through the reliable and more economic commercial supply of enzymes to Industrial Biotechnology using industries.

Informal Enquiries
For further details of how to apply, entry requirements and the application form, see
https://www.northumbria.ac.uk/research/postgraduate-research-degrees/how-to-apply/
Please ensure you quote the advert reference above on your application form.

Eligibility
For further details of how to apply, entry requirements and the application form, see
https://www.northumbria.ac.uk/research/postgraduate-research-degrees/how-to-apply/
Please ensure you quote the advert reference above on your application form.

How to Apply
For further details of how to apply, entry requirements and the application form, see
https://www.northumbria.ac.uk/research/postgraduate-research-degrees/how-to-apply/
Please ensure you quote the advert reference above on your application form.

Funding Notes

This studentship is only open to self-funding candidates. Self-funding candidates are expected to pay University fees and to provide their own living costs. In addition, a ‘bench fee’ will have to be paid to cover project running costs (at a level that will be determined specifically for each project).

References

Black GW, Brown NL, Perry JJB, Randall PD, Turnbull G, Zhang M (2015) A high-throughput screening method for determining the substrate scope of nitrilases. Chemical Communications 51, 2660-2662.

Yang Q, Zhang M, Harrington DJ, Black GW, Sutcliffe IC (2011) A proteomic investigation of Streptococcus agalactiae reveals that human serum induces the C protein β antigen and arginine deaminase. Microbes and Infection 13, 757-760.

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