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Activities of Bioactive Serpin Peptides (HLS/SE/DRFAPP7P/63606)

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  • Full or part time
    Dr Bass
  • Application Deadline
    Applications accepted all year round

Project Description

Serpins are a family of proteins which act as inhibitors of serine proteases. They have far reaching biological activities, influencing normal biological function and human disease. We have identified bioactive serpin peptides that impact on the functions of mammalian cells that are deregulated in the progression of diseases including cancer. Cell function assays to study migration, invasion, proliferation, apoptosis and adhesion are well established in the laboratory.

This project would involve the identification of novel targets and using established assays to determine the influence and biological activity of peptides in cell models of cancer and heart disease, in addition to determining anti-microbial activity.

Informal Enquiries
Enquiries regarding this studentship should be made to: Dr Rosemary Bass [email protected]
For further details of how to apply, entry requirements and the application form, see
https://www.northumbria.ac.uk/research/postgraduate-research-degrees/how-to-apply/
Please ensure you quote the advert reference above on your application form.

Eligibility
For further details of how to apply, entry requirements and the application form, see
https://www.northumbria.ac.uk/research/postgraduate-research-degrees/how-to-apply/
Please ensure you quote the advert reference above on your application form.

How to Apply
For further details of how to apply, entry requirements and the application form, see
https://www.northumbria.ac.uk/research/postgraduate-research-degrees/how-to-apply/
Please ensure you quote the advert reference above on your application form.

Funding Notes

This studentship is only open to self-funding candidates. Self-funding candidates are expected to pay University fees and to provide their own living costs. In addition, a ‘bench fee’ will have to be paid to cover project running costs (at a level that will be determined specifically for each project).

References

Ravenhill L, Wagstaff L, Edwards DR, Ellis V & Bass R. (2010) The G-helix of maspin mediates effects on
cell migration and adhesion. Journal of Biological Chemistry 285(47), 36285 - 92.

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