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Stress responses and toxicology in yeast

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  • Full or part time
    Prof Simon Avery
    Dr Dyer
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

This project is focused on understanding the effects of stress on cells, with emphasis on toxic metals, oxidants and drugs. We use the yeast Saccharomyces cerevisiae as an ideal eukaryotic model to characterize stress-effects at the whole-cell and molecular levels. This includes mode-of-action discovery with major drugs like current antimalarials.

This project will concentrate on stressor-induced oxidative stress as the main toxicity mechanism. This area is of particular interest considering the associations of oxygen free radicals with cancer, aging and a host of other degenerative conditions in humans.
The project will include analyses of the variability in stress responses seen among individual cells within populations. Cell individuality is a highly topical area being investigated by a number of laboratories across the world. We have pioneered innovative techniques to study it in this project.

Successful candidates will join an active group within the highly rated School of Life Sciences, University of Nottingham. The project will provide excellent training opportunities in recombinant DNA techniques (cloning, PCR, mutagenesis), genome-wide screening methods, bioinformatics, gene expression using fluorescent reporter proteins, flow cytometry/cell sorting (FACS), protein analysis, purification and immunoblotting.

Funding Notes

Home and EU applicants should contact the supervisor to determine the current funding status for this project. International applicants should visit our International Research Scholarships page for information regarding fees and funding at the University http://www.nottingham.ac.uk/studywithus/international-applicants/scholarships-fees-and-finance/scholarships/index.aspx.

References

Islahudin F, Tindall S, Mellor IR, Swift K, Christensen HEM, Fone KCF, Pleass RJ, Ting K-N and Avery SV (2014). The antimalarial drug quinine interferes with serotonin biosynthesis and action. Sci. Rep. (Nature) 4, Article 3618.
Holland SL, Reader T, Dyer PS and Avery SV (2014). Phenotypic heterogeneity is a selected trait in natural yeast populations subject to environmental stress. Environ. Microbiol. 16 Issue: 6, 1729-1740.
Alhebshi A, Sideri TC, Holland SL and Avery SV (2012). The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species. Mol. Biol. Cell 23, 3582-3590.
Avery SV (2011). Molecular targets of oxidative stress. Biochem. J. 434, 201-210.

How good is research at University of Nottingham in Biological Sciences?

FTE Category A staff submitted: 90.86

Research output data provided by the Research Excellence Framework (REF)

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