• University of East Anglia Featured PhD Programmes
  • University of Cambridge Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
  • Aberdeen University Featured PhD Programmes
  • Castelldefels School of Social Sciences Featured PhD Programmes
  • University of Birmingham Featured PhD Programmes
Ludwig-Maximilians-Universität Munich Featured PhD Programmes
Coventry University Featured PhD Programmes
Imperial College London Featured PhD Programmes
Imperial College London Featured PhD Programmes
University of Reading Featured PhD Programmes

Recognition of bacterial biofilms by innate immune cells

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Dr L Martinez-Pomares
    Prof M Camara
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

P.aeruginosa (PA) is emerging as major opportunistic pathogen of clinical relevance. Acute PA infection is particularly serious in patients suffering from ventilator-associated pneumonia and chemotherapy-associated neutropenia (1,2). PA also causes chronic infection in cystic fibrosis (CF) patients where the lack of effective mucocilliary clearance and intensive antibiotic treatment provides a unique niche for PA to persist leading to the generation of PA strains highly adapted to the CF lung (3). PA causes a resilient infection difficult to eradicate because of the intrinsic resistance of PA to antibiotics, its ability to produce a wide range of virulence factors including toxins, proteases and lipids and form biofilms (3). Biofilms represent a formidable adversary for innate immune cells responsible for bacterial clearance, macrophages and neutrophils and can lead to the induction of chronic inflammation (4). To better understand the ability of biofilms to modulate the inflammatory response, this project aims to study the interaction of PA biofilms with human innate immune cells. We will determine how immune cells influence biofilms by assessing biofilm development in the presence of immune cells and conversely, how biofilms modulate the activation of human macrophages and neutrophils by assessing cytokine production, cell survival (5) and formation of extracellular nets in biofilms-immune cells co-cultures.

Funding Notes

Home and EU applicants should contact the supervisor to determine the current funding status for this project. International applicants should visit our page for information regarding fees and funding at the University http://www.nottingham.ac.uk/studywithus/international-applicants/scholarships-fees-and-finance/scholarships/index.aspx


1. Kerr, K. G., and Snelling, A. M. (2009) J Hosp Infect 73(4), 338-344
2. Williams, B. J., Dehnbostel, J., and Blackwell, T. S. (2010) Respirology 15(7), 1037-1056
3. Folkesson, A., Jelsbak, L., Yang, L., Johansen, H. K., Ciofu, O., Hoiby, N., and Molin, S. (2012) Nat Rev Microbiol 10(12), 841-851
4. Watters, C., Everett, J. A., Haley, C., Clinton, A., Rumbaugha, K.P. (2014) Infect Immun Jan;82(1):92-100.
5. Singh, S., Barr, H., Liu, Y.-Ch., Robins, A., Heeb, S., Williams, P., Fogarty, A., Cámara, M., Martínez-Pomares, L.. (2015). PLoS One. Feb 23;10(2):e0117447. doi: 10.1371/journal.pone.0117447. eCollection 2015.

How good is research at University of Nottingham in Biological Sciences?

FTE Category A staff submitted: 90.86

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Cookie Policy    X