Metabolic effects of overnutrition during physical inactivity
Dr F Stephens
Prof IA Macdonald
Applications accepted all year round
Self-Funded PhD Students Only
Physical inactivity is a significant predictor of major non-communicable diseases such as type 2 diabetes, cardiovascular disease, musculoskeletal disorders and some cancers, and has been proposed to be the 4th leading cause of death worldwide. Reduced physical activity leads to an impaired metabolic response of skeletal muscle to insulin and nutrition (insulin and anabolic resistance), as well as a loss of skeletal muscle mass and function. Physical inactivity also leads to the accumulation of various lipid species within muscle cells. These metabolic perturbations are also observed with over feeding i.e. both scenarios create a positive energy balance. The purpose of the present proposal is to elucidate the contribution of overfeeding to the negative effects of physical inactivity. The project will involve a series of in vivo metabolic physiology studies to assess insulin sensitivity, nutrient sensitivity, and physical function in healthy young human participants before and after dramatically reducing their habitual physical activity levels during under and over feeding.
Home and EU applicants should contact the supervisor to determine the current funding status for this project. International applicants should visit our page for information regarding fees and funding at the University http://www.nottingham.ac.uk/studywithus/international-applicants/scholarships-fees-and-finance/scholarships/index.aspx
How good is research at University of Nottingham in Biological Sciences?
FTE Category A staff submitted: 90.86
Research output data provided by the Research Excellence Framework (REF)
Click here to see the results for all UK universities