Developing a non-invasive measurement of skeletal muscle health in humans
Dr F Stephens
Prof IA Macdonald
Applications accepted all year round
Self-Funded PhD Students Only
The loss of muscle mass and physical function is a common feature of ageing and numerous inflammatory and hypermetabolic conditions, such as cancer. Muscle loss and weakness is often associated with lipid accumulation in and around the muscle. This lipid accumulation can be measured non-invasively using radiological CT or MRI imaging. Indeed, several studies have demonstrated that gross increases in muscle lipid content measured using CT imaging have been linked to reduced muscle strength and function, as well as prognostic for poor survival in large cohorts of patients with cancer or other wasting diseases. However, such imaging is expensive and time consuming and there is a need for non-invasive measures of muscle lipid content and health. The aim of the present project is to perform a series of metabolic physiology studies in healthy human participants aimed at manipulating muscle lipid content in order to validate a novel bioelectrical impedance technology at assessing skeletal muscle lipid content.
Home and EU applicants should contact the supervisor to determine the current funding status for this project. International applicants should visit our page for information regarding fees and funding at the University http://www.nottingham.ac.uk/studywithus/international-applicants/scholarships-fees-and-finance/scholarships/index.aspx
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