The School of Life Sciences, University of Lincoln, is seeking a highly motivated individual to embark on a 3 year PhD project investigating genome-wide determinants of neuronal functional decline during neurodegeneration. This project will investigate the temporal patterns of gene activity associated with functional decline and is part of a wider research programme aimed at identifying molecular determinants of long term cell survival and maintenance in the nervous system.
During this project, we will employ a combination of bioinformatics tools, transcriptomics, functional genomics and gene network analysis approaches to analyse gene expression profiles derived from next generation sequencing (RNA-seq) in addition to functional data derived from brain tissues from both animal and human models.
The results from this project will provide critical insights on the genetic and molecular determinants of general neuronal longevity as well as functional decline during pathological conditions such as neurodegeneration.
We welcome applications from candidates with a good degree in any area of the Life Sciences disciplines including Neuroscience, Bioinformatics or Genomics as well as graduates from Computer Sciences degrees and also from individuals with a Master degree in a related discipline.
The successful candidate should be able to think critically and work independently and in collaboration. He or she will join a wider research group working on projects linking complex nervous system phenotypes to genomic features. The project will be conducted at the University of Lincoln but students will also be invited to undertake additional training and research work at the University of Bath UK as well as potentially visit overseas research partners. During this project, the student will also gain expertise in the use of programming languages including Matlab, R, Python and others as well as state of the art available bioinformatics tools to perform genome wide transcriptome and gene network analysis.
Dr Humberto Gutierrez (School of Life Sciences, email: [email protected]
) will be the primary supervisor, Dr Araxi Urrutia (University of Bath) and Dr Matthew Simmonds (U of Lincoln, UK) will act as co-supervisors.
We are currently inviting applications for a fully funded studentship to be awarded on a competitive basis for students to start October 2016.
Deadline for final submission: 22nd April 2016.
Interviews are expected to take place between 25th and 29th of April
A stipend of £14,124 per annum for three years plus fees for both home and international students for three years will be covered by this studentship,
To apply contact Dr Humberto Gutierrez ([email protected]) for an informal discussion of the application/proposal prior to formal submission or submit a CV and a Cover Letter, no later than 22nd of April.