• University of Warwick Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
  • University of Greenwich Featured PhD Programmes
  • University of Manchester Featured PhD Programmes
  • Lancaster University Featured PhD Programmes
  • University of Birmingham Featured PhD Programmes
  • Ross University School of Veterinary Medicine Featured PhD Programmes
  • University of Tasmania Featured PhD Programmes
IMT Institute for Advanced Studies Lucca Featured PhD Programmes
University of Glasgow Featured PhD Programmes
University of Southampton Featured PhD Programmes
Coventry University Featured PhD Programmes
University of Tasmania Featured PhD Programmes

Mechanobiology of cardiac interstitial cells

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Dr S Hafizi
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Apart from myocytes and vascular cells, the heart is also composed in large part of fibroblasts or interstitial cells (ICs); these are dynamic cells, with the ability to sense and respond to the environment profoundly in a variety of ways, e.g. differentiation, proliferation, matrix secretion and contraction. In this PhD project, we will study the genotypic and phenotypic differences between ICs from human hearts with different pathologies where IC remodelling features highly, e.g. myocardial infarction, cardiomyopathies, aortic valvular disease. This knowledge about the properties of those different IC populations could lead to novel and more effective therapies for those distinct cardiac diseases.

This project will be most suitable for a student with an interest in biomedical research, further enhanced by an interest in cellular biomechanics. The student will join a vibrant research environment within the university’s Institute of Biomedical and Biomolecular Science (IBBS), with close links to the School of Engineering. The project will employ in vitro cultures of human heart ICs from a variety of pathologies, which the student will study using various cell and molecular assays to determine the cells’ phenotypes in response to both humoral and mechanical stimulation, to reproduce the conditions within the heart wall. To this end, the student shall be trained in a range of biochemical and cell biological techniques, including cell culture, molecular expression analyses, immunohistochemical techniques, confocal microscopy, and biomechanical models.

In addition you will have access to a skills development program run by the university’s Graduate School. The experimental and analytical skills developed during this project will prepare the student well for a future career in academia or industry.

Research Group website: http://www.port.ac.uk/institute-of-biomedical-and-biomolecular-science/cell-biology-and-pharmacology/sassan-hafizi/

Funding Notes

Self funded - University fees (currently, £13,100 for International Students and £4,052 for Home and EU students). Potential part-funding can also be considered depending on the individual applicant.

How good is research at University of Portsmouth in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 23.80

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Cookie Policy    X