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Metallacycle Precatalysts for Lead-Oriented Synthesis (RICHARDSU16SF)

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  • Full or part time
    Dr C Richards
  • Application Deadline
    No more applications being accepted
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Previous work within the Richards group has resulted in the synthesis of chiral non-racemic metallacycles and metallocenes which are novel catalysts and potential precatalysts for use in asymmetric synthesis.1-5 Catalysis enables: it opens up new areas of ‘chemical space’, increases efficiency, and provides control, above all stereocontrol, for the generation of non-racemic compounds. But the search for an ‘optimised’ catalyst that can give rise to a single product enantiomer with a catalyst loading of <1mol% remains very difficult and time consuming. This PhD project will address this challenge with the development of a novel two-step diversity generating catalyst synthesis protocol. The resulting catalysts will be applied to the development of new procedures for the synthesis of chiral lead-like structures for application in collaborative drug-discovery programmes.

Funding Notes

This project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources. Details of tuition fees can be found at http://www.uea.ac.uk/pgresearch/pgrfees.

A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. The amount charged annually will vary considerably depending on the nature of the project and applicants should contact the primary supervisor for further information about the fee associated with the project.

References

i) D. J. Cassar, H. Roghzai, D. Villemin, P. N. Horton, S. J. Coles and C. J. Richards, Organometallics 2015, 34, 2953-2961.
ii) D. J. Cassar, G. Ilyashenko, M. Ismail, J. Woods, D. L. Hughes and C. J. Richards, Chem. Eur. J. 2013, 19, 17951-17962.
iii) J. Amin and C. J. Richards, Chem. Commun. 2012, 48, 10192-10194.
iv) N. Dendele, F. Bisaro, A.-C. Gaumont, S. Perrio and C. J. Richards, Chem. Commun. 2012, 48, 1991-1993.
v) H. Nomura and C. J. Richards, Chem. Asian J. 2010, 5, 1726-1740.

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