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The role of biofilm formation in Ureaplasma spp. pathogenesis

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  • Full or part time
    Dr Michael Beeton
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Biofilm formation is a key survival strategy utilised by numerous bacterial pathogens. Existence in these sessile microbial communities has been shown to give increased protection against antimicrobial therapy as well as the host immune system resulting in chronic infection. Understanding the basic biology of these systems is key to the prevention, and more problematic, clearance of these structures.

This project will utilise varying static and flow based methods for analysing conditions for biofilm formation in both biotic and abiotic situations. On establishment of biofilms we will use state-of-the art confocal laser scanning microscopy (CLSM) to examine the three dimensional structure, biochemical assays to determine the composition of extracellular matrix and examine the efficacy of antimicrobials to remove the biomass.

References

Beeton ML, Aldrich-Wright JR, Bolhuis A. The antimicrobial and antibiofilm activities of copper(II) complexes. J Inorg Biochem. 2014 Nov;140:167-72.

Beeton ML, Daha MR, El-Shanawany T, Jolles SR, Kotecha S, Spiller OB. Serum killing of Ureaplasma parvum shows serovar-determined susceptibility for normal individuals and common variable immuno-deficiency patients. Immunobiology. 2012 Feb;217(2):187-94.

Beeton ML, Chalker VJ, Maxwell NC, Kotecha S, Spiller OB. Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. Antimicrob Agents Chemother. 2009 May;53(5):2020-7.

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