• University of Birmingham Featured PhD Programmes
  • University of Manchester Featured PhD Programmes
  • Coventry University Featured PhD Programmes
  • Ross University School of Veterinary Medicine Featured PhD Programmes
  • FindA University Ltd Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
Ludwig-Maximilians-Universität Munich Featured PhD Programmes
Imperial College London Featured PhD Programmes
EPSRC Featured PhD Programmes
FindA University Ltd Featured PhD Programmes
FindA University Ltd Featured PhD Programmes

The role of biofilm formation in Ureaplasma spp. pathogenesis

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Dr Michael Beeton
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Biofilm formation is a key survival strategy utilised by numerous bacterial pathogens. Existence in these sessile microbial communities has been shown to give increased protection against antimicrobial therapy as well as the host immune system resulting in chronic infection. Understanding the basic biology of these systems is key to the prevention, and more problematic, clearance of these structures.

This project will utilise varying static and flow based methods for analysing conditions for biofilm formation in both biotic and abiotic situations. On establishment of biofilms we will use state-of-the art confocal laser scanning microscopy (CLSM) to examine the three dimensional structure, biochemical assays to determine the composition of extracellular matrix and examine the efficacy of antimicrobials to remove the biomass.


Beeton ML, Aldrich-Wright JR, Bolhuis A. The antimicrobial and antibiofilm activities of copper(II) complexes. J Inorg Biochem. 2014 Nov;140:167-72.

Beeton ML, Daha MR, El-Shanawany T, Jolles SR, Kotecha S, Spiller OB. Serum killing of Ureaplasma parvum shows serovar-determined susceptibility for normal individuals and common variable immuno-deficiency patients. Immunobiology. 2012 Feb;217(2):187-94.

Beeton ML, Chalker VJ, Maxwell NC, Kotecha S, Spiller OB. Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. Antimicrob Agents Chemother. 2009 May;53(5):2020-7.

How good is research at Cardiff Metropolitan University in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 12.00

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Cookie Policy    X