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The role of endocytic trafficking in ActivinA signalling

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  • Full or part time
    Dr C Murphy
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

A PhD project is offered in the general area of membrane trafficking and signalling. Currently our main interest focuses on the role of the endocytic pathway in TGF-β/Activin A receptor signalling due to their involvement in angiogenesis, carcinogenesis and development. We are especially interested in understanding the role of endocytic trafficking during pluripotency and differentiation and therefore use human embryonic stem cells, human induced pluripotent stem cells and mature primary endothelial cells. Technical approaches include cloning, protein expression, general Cell Biology, CRISPR knockout, Imaging etc.

Key words: membrane trafficking, differentiation, pluripotency, angiogenesis

Please find additional funding text below. For further funding details, please see the ‘Funding’ section.
The School of Biosciences offers a number of UK Research Council (e.g. BBSRC, NERC) PhD studentships each year. Fully funded research council studentships are normally only available to UK nationals (or EU nationals resident in the UK) but part-funded studentships may be available to EU applicants resident outside of the UK. The deadline for applications for research council studentships is 31 January each year.

Each year we also have a number of fully funded Darwin Trust Scholarships. These are provided by the Darwin Trust of Edinburgh and are for non-UK students wishing to undertake a PhD in the general area of Molecular Microbiology. The deadline for this scheme is also 31 January each year.

Funding Notes

All applicants should indicate in their applications how they intend to fund their studies. We have a thriving community of international PhD students and encourage applications at any time from students able to find their own funding or who wish to apply for their own funding (e.g. Commonwealth Scholarship, Islamic Development Bank).

The postgraduate funding database provides further information on funding opportunities available http://www.birmingham.ac.uk/postgraduate/funding/FundingFilter.aspx and further information is also available on the School of Biosciences website http://www.birmingham.ac.uk/schools/biosciences/courses/postgraduate/phd.aspx

References

Sflomos G, Kostaras E, Panopoulou E, Pappas N, Kyrkou A, Politou AS, Fotsis T, Murphy C: ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN. J Cell Sci 2011, 124:3209-3222.
Kostaras E, Sflomos G, Pedersen NM, Stenmark H, Fotsis T, Murphy C: SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking. Oncogene 32 (2013) 5220-32.
Karali E, Bellou S, Stellas Dimitris, Klinakis Apostolos Murphy C, Fotsis T: ER mediates induction of endothelial cell survival and angiogenesis by VEGF: PLCg via mTORC1 activates ATF6 and PERK. Mol. Cell 54 (2014) 559-72.

Related Subjects

How good is research at University of Birmingham in Biological Sciences?

FTE Category A staff submitted: 42.80

Research output data provided by the Research Excellence Framework (REF)

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